The immediate effects of various types of vagotomy and gastrojejunostomy on gastric secretion and gastric ulceration after pyloric ligation were studied in albino rats.
In the present experiment animals were divided into two groups, namely the control and experimental. Pyloric ligation only in the control group was performed. Experimental group was further divided into four groups according to the operative procedures made in addition to ligation of the pylorus as follows: Group I subjected to left truncal vagotomy, group II subjected to right truncal vagotomy, group in subjected to bilateral truncal vagotomy, and goup IV subjected to gastrojejunostomy.
The secretory and ulcerogenic potentials of the experimental groups were compared with those of the control group.
The results were summarized as follows:
1. In the control group the mean pH was 2.36, the mean acidity was 43.37 mEq/ 1, and gastric ulcers were found in all rats.
2. In the group I the mean pH was 2.83, the mean acidity was 33. 56 mEq/l, and gastric ulcers developed in 76.92 per cent.
3. In the group II the mean pH was 2.87, the mean acidity was 29. 10 mEq/1, and gastric ulcers developed in 61. 54 per cent.
4. In the group IQ the mean pH was 4.45, the mean acidity was 12.77 mEq/1, and no gastric ulcers developed in all rats.
5. In the group IV the mean pH was 2.93, the mean acidity was 28.86 mEq/1, and gastric ulcers developed in 69.23 per cent.
6. In the groups I , II and IV acid secretion was reduced as compared with that of the control group but ulcers developed, whereas in the group In acid secretion was markedly reduced and no ulcers developed.
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